By Avi Ashkenazi, Junying Yuan, Jim Wells
Regulated telephone demise half A & half B of equipment in Enzymology maintains the legacy of this optimum serial with caliber chapters authored by way of leaders within the box. This quantity covers study equipment in apoptosis targeting the real parts of intrinsic pathway, extrinsic pathway, caspases, mobile assays and post-apoptotic results and version organisms; in addition to issues on necroptosis and screening approaches.
- Continues the legacy of this most effective serial with caliber chapters authored via leaders within the box
- Covers learn equipment in biomineralization science
- Regulated mobilephone demise half A & half B includes sections on such themes as apoptosis targeting the real parts of intrinsic pathway, extrinsic pathway, caspases, mobile assays and post-apoptotic results and version organisms; in addition to subject matters on necroptosis and screening methods
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Additional resources for Regulated cell death Part A : apoptotic mechanisms
Science, 274, 948–953. LaBelle, J. , Katz, S. , Bird, G. , Stewart, M. , et al. (2012). A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. Journal of Clinical Investigation, 122, 2018–2031. Laskowski, R. , Rullmannn, J. , MacArthur, M. , & Thornton, J. M. (1996). AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR. Journal of Biomolecular NMR, 8, 477–486. Leshchiner, E. , Braun, C. , Bird, G. , & Walensky, L. D. (2013). Direct activation of full-length proapoptotic BAK.
Mootha, V. , et al. (2000). tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes & Development, 14, 2060–2071. , Harrison, S. , Skehel, J. , & Wiley, D. C. (1997). Atomic structure of the ectodomain from HIV-1 gp41. Nature, 387, 426–430. Yates, J. , Eng, J. , McCormack, A. , & Schieltz, D. (1995). Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database. Analytical Chemistry, 67, 1426–1436. CHAPTER THREE The Structural Biology of BH3-Only Proteins Marc Kvansakul*,1, Mark G.
1% TFA. g. Elute by carefully pipetting up and down in a prepared elution tube three times. h. Dry the eluate by speed-vac. We use a split flow LC system with in-house packed C4/C18 columns for MS analysis on a Thermo LTQ Orbitrap Discovery mass spectrometer. Samples are reconstituted in 5% ACN/5% FA and loaded onto the LC. 5 mm C4 (Sepax 5 mm, 120 A˚) and then C18 slurry (Nest 3 mm, ˚ ). 125% FA/ACN. We typically employ a 2 h gradient from 10% to 40% B with a top 10 data-dependent method. Analysis of the MS/MS spectra can be accomplished using the SEQUEST algorithm (Eng, McCormack, & Yates, 1994; Yates, Eng, 38 Susan Lee et al.