By V. Thongboonkerd, C. Ronco
Because the ebook of the 1st quantity on proteomics in nephrology, methodologies and protocols for renal and urinary proteome analyses were constantly more advantageous, leading to substantial growth in the direction of medical software. Proteomics not just contributes to a greater knowing of the renal body structure and pathogenic mechanisms of kidney illnesses, but in addition assists within the look for novel biomarkers for diagnostics and prognostics and helps the definition and improvement of recent healing goals and medicine for higher healing end result. whereas the 1st quantity targeted as a rule on an summary, applied sciences and methodologies, this quantity highlights winning functions of proteomics to a number of kidney ailments, together with acute kidney damage, nephrotic syndrome, diabetic nephropathy, renal allograft rejection, renal telephone carcinoma, obstructive nephropathy, kidney stone disorder, uremia, and others. Written by means of acclaimed specialists in proteomics and nephrology, this e-book is a wonderful source of references for nephrologists, clinicians, pharmacists, different healthcare pros, proteomists, physiologists, scientists, and trainees.
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Additional resources for Proteomics in Nephrology: Towards Clinical Applications (Contributions to Nephrology)
We suspected that the source of contamination was from the original urine containers used in the clinic setting prior to transfer to MS-friendly cryotubes. This problem would not necessarily have manifested in plasma studies, as blood is collected in glass tubes where PEG is not a concern. We next focused on removing the contaminating PEG. We felt that dialysis of the samples would have given inconsistent removal and also was counter to our goal of developing a high-throughput to working with nephrotic urine.
Kidney Int 2004;65:2426–2434. Ransom RF, Lam NG, Hallett MA, et al: Glucocorticoids protect and enhance recovery of cultured murine podocytes via actin filament stabilization. Kidney Int 2005;68:2473–2483. Ramjee G, Coovadia HM, Adhikari M: Comparison of noninvasive methods for distinguishing steroid-sensitive nephrotic syndrome from focal glomerulosclerosis. J Lab Clin Med 1997;129: 47–52. Khurana M, Traum AZ, Aivado M, et al: Urine proteomic profiling of pediatric nephrotic syndrome. Pediatr Nephrol 2006;21:1257–1265.
These toxicities are myriad and include such problems as growth impairment, behavior changes, obesity, hypertension, glucose intolerance, bone disease, and others. Second, differentiating biomarkers may offer insight into the pathophysiology of NS. This has been a subject of intense research, with interest in such diverse processes as dysregulated immune function, mutations in podocyte proteins, lipid disorders, and angiogenesis. Proteomics has provided an ideal platform to identify and study noninvasive biomarkers.