By Dennis A. Wigle Ph.D., Igor Jurisica Ph.D. (auth.), Igor Jurisica PhD, Dennis A. Wigle MD, Bill Wong BSc, MBA (eds.)
Medical info technology calls for analytic instruments. this is often completed by way of constructing and assessing tools and platforms for the purchase, processing, and interpretation of sufferer information, aided via medical discovery. Cancer Informatics in Post-Genomic Era presents either the mandatory method and sensible details instruments.
Key demanding situations contain integrating study and scientific care, sharing information, and setting up partnerships inside and throughout sectors of sufferer analysis and remedy.
Addressing vital scientific questions in melanoma learn will take advantage of increasing computational biology.
The introduction of genomic and proteomic applied sciences has ushered forth the period of real medication. The promise of those advances is correct "personalized medication" the place therapy techniques will be separately adapted and increase to beginning intervention prior to seen indicators seem.
Series editor comments:
"Cancer informatics has develop into a serious element of sleek investigations. a mix of system's biology and the significance of information units linked to melanoma study require refined applied sciences to control the vast spectrum of collective wisdom. this article offers a entire evaluate of the sphere provided via leaders within the discipline."
Steven T. Rosen, M.D.
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Additional resources for Cancer Informatics in the Post Genomic Era: Toward Information-Based Medicine
Viable tissue/cells may be banked by cryopreservation, as primary or propagable cell lines, or in the form of living xenograft tumors in immune deficient rodents. Each of these tissue-banking strategies has their respective advantages or disadvantages. Paraffin embedded tissue bank Throughout the world, there already exist in the Department of Pathology of every hospital, a very large bank of fixed human tissue representing all types of diseases. These paraffin embedded archival tissues are generally prepared using a standard histopathology protocol, as part of the routine surgical pathology practices.
This entails the design of studies aimed at assessing tumor response to drugs or other agents known to have efficacy in patients with the particular type of cancer represented by the model. The H460 orthotopic lung cancer model has been validated (Johnston, Mullen et al. 2001) by treating tumorbearing nude rats with one of four chemotherapy agents: doxorubicin, In Vivo Systems for Studying Cancer 39 mitomycin, cisplatin, and the novel matrix metalloproteinase inhibitor, batimastat. The model shows consistent responses in the context of tumor weight, metastatic pattern and longevity to cisplatin and mitomycin treatment.
Cell lines appear easier to establish from advanced, poorly differentiated and metastatic cancers. The ability to establish cell line from the tumor has been reported to be a poor prognostic marker in NSCLC patients. Thus, although tumor cell lines demonstrate the genetic aberrations noted also in primary tumors, they may not be representative of the entire spectra of expression changes found in primary human tumors. Genome wide microarray studies have demonstrated that the expression profiles of cell lines tend to segregate separately from that of the primary tumors of same tumor type.