By Daniel Erik Otzen
Summing up nearly a decade of biomedical learn, this topical and eagerly awaited guide is the 1st reference at the subject to include fresh breakthroughs in amyloid study.
the 1st half covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, together with an outline of present versions for amyloid formation. the second one half appears on the analysis and biomedical research of amyloid in people and in animal versions, whereas the ultimate part discusses pharmacological ways to manipulating amyloid and in addition appears to be like at its physiological roles in reduce and better organisms.
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Extra resources for Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties
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19 21 2 Amyloid Structures at the Atomic Level: Insights from Crystallography Michael R. 1 Atomic Structures of Segments of Amyloid-Forming Proteins Current understanding of the molecular organization of amyloid ﬁbers has come from application of numerous biochemical and biophysical methods. In this chapter, however, we focus almost entirely on the information from single-crystal X-ray diffraction. Because they are conformationally heterogeneous, entire amyloid ﬁbers cannot be crystallized and, hence, are unsuitable for single-crystal diffraction.