By Carol Bernstein, Harris Bernstein
Why organisms age and why sexual copy exists are significant unsolved difficulties in biology. This ebook presents an built-in clarification of getting older and intercourse according to present wisdom of DNA harm and service. Key positive factors* Discusses the universality of the matter of DNA harm* Describes getting older because of accrued DNA harm* Considers meiosis as an version for DNA fix* Discusses mating in eukaryotes as an edition for covering mutation. Read more...
Read Online or Download Aging, Sex, and DNA Repair PDF
Best molecular biology books
Telomerase: evolution, constitution, and serve as / Marie-Eve Brault, Yasmin D'Souza, and Chantal Autexier -- Drosophila telomeres: a edition at the telomerase subject matter / Mary-Lou Pardue and P. Gregory DeBaryshe -- replacement lengthening of telomeres in mammalian cells / Anthony J. Cesare and Roger R. Reddel -- T-loops, T-circles, and slippery forks / Sarah A.
This quantity within the well-established tools in Enzymology sequence gains equipment for the research of lipids utilizing mass spectrometry ideas. Articles during this quantity hide themes similar to Qualitative research and Quantitative review of alterations in impartial Glycerol Lipid Molecular Species inside Cells; Glycerophospholipid identity and quantitation by way of electrospray ionization mass spectrometry; Detection and Quantitation of Eicosanoids through excessive functionality Liquid Chromatography/Electrospray Ionization Mass Spectrometry; Structure-specific, quantitative tools for "lipidomic" research of sphingolipids by way of tandem mass spectrometry; research of Ubiquinones, Dolichols and Dolichol Diphosphate-Oligosaccharides by means of Liquid Chromatography Electrospray Ionization Mass Spectrometry; Extraction and research of Sterols in organic Matrices by way of High-Performance Liquid Chromatography Electrospray Ionization Mass Spectrometry; The Lipid Maps Initiative in Lipidomics; easy analytical structures for lipidomics by means of mass spectrometry in Japan; the eu Lipidomics Initiative allowing applied sciences; Lipidomic research of Signalling Pathways; Bioinformatics for Lipidomics; Mediator Lipidomics: seek Algorithms for Eicosanoids, Resolvins and Protectins; A advisor to biochemical structures modeling of sphingolipids for the biochemist; and Quantitation and Standardization of Lipid inner criteria for Mass Spectroscopy.
How does a single-cell creature, resembling an amoeba, lead this kind of refined lifestyles? How does it hunt residing prey, reply to lighting, sounds, and scents, and reveal advanced sequences of hobbies with out the advantage of a frightened approach? This publication bargains a startling and unique resolution. In transparent, jargon-free language, Dennis Bray faucets the findings of the recent self-discipline of structures biology to teach that the interior chemistry of dwelling cells is a kind of computation.
This ebook covers the most recent advancements in enzyme immobilization with its huge functions, similar to for undefined, agriculture, medication, and the surroundings. subject matters lined contain fundamentals of enzyme immobilization, its implication in therapeutics and disorder diagnostics, and its importance in fixing environmental difficulties.
- The Sugar Code - Fundamentals of Glycosciences
- Tight Junctions (Molecular Biology Intelligence Unit)
- Amyloid Prions and Other Protein Aggregates
- Protein prenylation: Part B
- Phage Display of Peptides and Proteins: A Laboratory Manual
- Developing Therapeutics for Alzheimer’s Disease. Progress and Challenges
Extra resources for Aging, Sex, and DNA Repair
1976), a progressive increase in sensitivity to digestion by the e n z y m e w a s found with age of the mice. This indicates that mice a c c u m u l a t e single-strand regions in their heart D N A as they age. Mori and G o t o (1982), h o w e v e r , could not repeat this Si e n d o n u c l e a s e result. T h e basis for this discrepancy is unclear. 48 I Accumulation of DNA Damage in Somatic Cells Zahn et al. (1987) studied age-correlated D N A damage in human muscle tissue. D N A damage was determined as D N A alterations that give rise to complete molecular b r e a k s during the treatment of purified D N A solutions with single-strand-specific nucleases.
T h e a u t h o r s concluded that a large proportion of the D N A in small n e u r o n s of the cerebellum undergoes no metabolic t u r n o v e r during the h u m a n life span. Other studies, reviewed by Slatkin et al. (1985), also have shown that in vivo most m o u s e brain neuronal D N A is metabolically stable. 1 3 1 2 1 3 1 2 1 3 I 2 Altogether, low D N A repair capacity w a s shown in all 10 studies on neuronal tissue (for s u m m a r y , see Table III). T h e results with neuronal tissue, both in vivo and in culture, were even clearer than the results on postmitotic muscle tissue (reviewed in this chapter, Section I L A ) .
G. (1980). Inhibition and recovery of DNA synthesis in UV-irradiated Chinese hamster V-79 cells. Photochem. Photohiol. 32, 157-165. Friedberg, E. C. (1985). " W. H. Freeman and Company, New York. , and Sauerbier, W. (1976). A radiobiological analysis of the transcription units for heterogeneous nuclear RNA in cultured murine cells. Cell 9, 775-783. References ! 35 Hackett, P. , and Sauerbier, W. (1975). The transcriptional organization of the ribosomal RNA genes in mouse L cells. J. Mol. Biol. 91, 235256.