By T. Hugh Jones
Testosterone has a major impact on significant organ platforms and tissues, together with mind, metabolism, cardiovascular in addition to musculoskeletal and immune platforms. protecting many scientific parts, this publication will pay specific awareness to the analysis and administration of hypogonadism, discussing present directions, biochemical overview, new innovations in testosterone substitute treatment and long term tracking of taken care of males. in addition the position of testosterone deficiency in getting older, weight problems, muscle functionality and frailty and erectile disorder is covered.Recent proof for the function of testosterone within the pathogenesis of continual illnesses similar to diabetes, heart problems and osteoporosis is stated. New advancements within the power remedy of those scientific stipulations also are. provided. essentially of curiosity to endocrinologists, urologists, andrologists and sexologists, the variety of themes lined can be suitable to basic care physicians, gerontologists, diabetologists and cardiologists.
Read or Download Advances in the Management of Testosterone Deficiency (Frontiers of Hormone Research Vol 37) PDF
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Extra resources for Advances in the Management of Testosterone Deficiency (Frontiers of Hormone Research Vol 37)
Salivary Testosterone In all probability salivary testosterone reflects a measure of the concentration of free, non-protein-bound circulating testosterone with levels in the 200–400 pmol range. To date it is unlikely that multichannel immunoassay analyzers can adapt plasma methodology to accommodate assays in saliva with such low concentrations and in a non-protein matrix. 0 nmol/l  it would appear that a considerably more sensitive assay would be required. There may be scope for applying GC/MS techniques to salivary samples.
Safety Safety data are available for the 1% testosterone gel . After 3 years of treatment, levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides remained unchanged. Levels of prostate-specific antigen (PSA) rose in proportion to the increase of testosterone levels but did not exceed normal values. These data collected in prospective well-designed large-scale studies are relatively rare in the area of testosterone treatment of male hypogonadism.
Ch) where both bioavailable and free testosterone concentrations are calculated automatically following insertion of concentrations of total testosterone, SHBG and albumin in pre-prepared calculator inserts. These calculations are based on the formula derived at the University of Ghent, Belgium . Whether this method of calculating bioavailable testosterone in all men is the most appropriate has recently been questioned . This report indicates an age-related discrepancy between measured and calculated bioavailable testosterone where the calculated concentration was found to be higher than the measured concentration, probably due to an age-related decrease in adrenal androgens.