Download Actin-Monomer-Binding Proteins by Pekka Lappalainen PDF

By Pekka Lappalainen

This ebook offers a finished view on actin monomer-binding proteins and the mechanisms through which they give a contribution to actin dynamics and numerous actin-dependent mobile methods. This new identify includes chapters that describe the elemental mechanisms of actin dynamics in addition to the structural rules through which a number of actin-binding proteins engage with actin. The publication is appropriate extra examining for college kids in complex cellphone biology classes.

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Furthermore, finding new functions for actin within the cell that are modulated by AC, such as Golgi membrane dynamics and mitochondrial leakage of cytochrome c, suggests that we have only begun to scratch the surface in our understanding of signaling pathways that can regulate AC proteins. This is particularly true of the pathways that regulate nuclear targeting of actin. Roles for nuclear actin are emerging as part of chromatin remodeling complexes and in transcription, and the AC proteins, with their nuclear localization signal, are prime candidates for delivery of actin to the nucleus.

Meberg PJ, O n o S, Minamide LS et al. Actin depolymerizing factor and cofilin phosphorylation dynamics: Response to signals that regulate neurite extension. Cell Motil Cytoskeleton 1998; 39(2):172-190. 58. Blanchoin L, Robinson RC, Choe S et al. Phosphorylation of Acanthamoeba actophorin (ADF/cofilin) blocks interaction with actin without a change in atomic structure. J Mol Biol 2000; 295(2):203-211. 59. Smertenko AP, Jiang CJ, Simmons NJ et al. Ser6 in the maize actin-depolymerizing factor, Z m A D F 3 , is phosphorylated by a calcium-stimulated protein kinase and is essential for the control of functional activity.

Actin filament disassembling activity of Caenorhabditis elegans actin-interacting protein 1 (UNC-78) is dependent on filament binding by a specific ADF/cofilin isoform. J Cell Sci 2003; l l 6 ( P t 20):4107-4118. 107. O n o S, Mohri K, O n o K. Microscopic evidence that actin-interacting protein 1 actively disassembles actin-depolymerizing factor/Cofilin-bound actin filaments. J Biol Chem 2004; 279(14):14207-14212. 108. Voegdi W C , Madrona AY, Wilson DK. T h e structure of A i p l p , a W D repeat protein that regulates Cofihn-mediated actin depolymerization.

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